Retatrutide (LY3437943) is a novel synthetic triple-agonist peptide that simultaneously activates GLP-1, GIP, and glucagon receptors. In the 48-week Phase 2 trial (n=338), the highest-dose cohort achieved 24.2% mean body weight reduction. CAS: 2381089-83-2.

How does the triple-agonist mechanism work?

GLP-1 promotes satiety signaling, GIP enhances insulin secretion, and glucagon increases hepatic energy expenditure and thermogenesis. This three-pathway approach addresses both energy intake and expenditure.

What is the price in Dubai?

AED 1,200 per pen, AED 3,300 for 3-pack (AED 1,100/pen), AED 5,000 for 5-pack (AED 1,000/pen). Same-day delivery in Dubai.

How should the FlexiPen be stored?

Store at +2 to +8 degrees Celsius. Do not freeze. Pre-filled pen — no reconstitution needed. 200 clicks at 0.1mg per click.

Triple-Agonist Research Peptide

ProPeptide Retatrutide

Name: ProPeptide Retatrutide 20mg FlexiPen
Brand: ProPeptide
SKU: PP-RETA-20MG

GLP-1 + GIP + Glucagon — Three Pathways, One Pen

The first triple-agonist peptide to reach Phase 2 clinical trials. Retatrutide simultaneously activates GLP-1 (satiety), GIP (insulin response), and glucagon (energy expenditure) receptors. Pre-filled FlexiPen with 200 precision clicks at 0.1mg each. Available in Dubai and across the UAE for in-vitro laboratory research.

20mg per pen COA Submitted Janoshik Analytical Same-day Dubai delivery

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ProPeptide · UAE stock

COA Submitted

Retatrutide 20mg FlexiPen

Triple-agonist research peptide — GLP-1 satiety + GIP insulin + Glucagon expenditure. Pre-filled pen, 200 clicks, cold-chain delivered. Dubai stock.

Compound

Retatrutide
CAS 2381089-83-2

Purity

COA Submitted
Janoshik Analytical

Format

Pre-filled pen
200 clicks × 0.1mg

Fulfilment

Same-day Dubai dispatch
Next-day other emirates

Pen

AED 1,200

per pen

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GLP-1 — Satiety

Activates hypothalamic appetite centres to promote satiety signalling. The same receptor targeted by semaglutide, but combined with two additional agonists for triple-pathway activation.

GIP — Insulin

Enhances glucose-dependent insulin secretion and improves beta-cell function. The metabolic layer absent from single-agonist compounds like semaglutide.

Glucagon — Expenditure

Increases hepatic energy expenditure, promotes lipolysis, and enhances thermogenesis. The unique third pathway that differentiates retatrutide from all other compounds.

Phase 2 — 24.2%

Mean body weight reduction at 48 weeks in the highest-dose cohort. 100% of participants achieved ≥5% weight loss at 24 weeks. Published NEJM 2023.

FAQ

Retatrutide FAQ

What is retatrutide?

Retatrutide (LY3437943) is a novel synthetic triple-agonist peptide that simultaneously activates GLP-1, GIP, and glucagon receptors. It is the first compound to target all three metabolic pathways in a single molecule. In the 48-week Phase 2 trial (n=338), the highest-dose cohort achieved 24.2% mean body weight reduction. CAS: 2381089-83-2.

How does triple agonism differ from semaglutide?

Semaglutide is a single-agonist (GLP-1 only). Tirzepatide is a dual-agonist (GLP-1 + GIP). Retatrutide is the first triple-agonist — activating GLP-1 for satiety signalling, GIP for insulin secretion, and glucagon for hepatic energy expenditure and thermogenesis. This three-pathway approach addresses both energy intake and expenditure simultaneously.

What is the purity?

COA has been submitted to Janoshik Analytical for independent HPLC analysis and identity confirmation. Results will be published on our COA library once testing is complete.

What are the pricing tiers?

AED 1,200 per pen (single), AED 3,300 for a 3-pack (AED 1,100/pen), AED 5,000 for a 5-pack (AED 1,000/pen). Same-day delivery in Dubai for orders placed before 4 PM, next-day across other UAE emirates. Payment and order confirmation via WhatsApp.

How should the pen be stored?

Store at +2 to +8°C (refrigerated). Do not freeze. The FlexiPen is pre-filled — no reconstitution needed. Each pen contains 20mg of retatrutide delivered across 200 precision clicks at 0.1mg per click. Cold-chain delivered to maintain integrity.

What Phase 2 data exists?

The pivotal Phase 2 trial was published in the New England Journal of Medicine (2023). 338 adults with obesity were randomised across multiple dose cohorts over 48 weeks. The highest-dose group achieved 24.2% mean body weight reduction. 100% of participants in that cohort achieved ≥5% weight loss by week 24. Secondary endpoints showed significant reductions in liver fat content and improvements in cardiometabolic markers.

Is retatrutide available in the UAE?

Yes. Retatrutide is available in Dubai and across the UAE for in-vitro laboratory research purposes under UAE MoHAP Circular 17/2022 governing research-use compounds. It is not approved for human consumption, therapeutic use, or veterinary use. See our UAE research peptide compliance guide for full detail.

Order Retatrutide — Dubai & UAE

20mg FlexiPen • COA submitted to Janoshik • From AED 1,000/pen • Same-day Dubai delivery • WhatsApp confirmation in minutes.

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